Single base pair change in the long-rangeSonic hedgehog limb-specific enhancer is a genetic basis for preaxial polydactyly
نویسندگان
چکیده
منابع مشابه
A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly.
Unequivocal identification of the full composition of a gene is made difficult by the cryptic nature of regulatory elements. Regulatory elements are notoriously difficult to locate and may reside at considerable distances from the transcription units on which they operate and, moreover, may be incorporated into the structure of neighbouring genes. The importance of regulatory mutations as the b...
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Patterning of the vertebrate limb along the anterior-posterior axis is controlled by the zone of polarizing activity (ZPA) located at the posterior limb margin. One of the vertebrate Hh family members, Shh, has been shown to be able to mediate the function of the ZPA. Several naturally occurring mouse mutations with the phenotype of preaxial polydactyly exhibit ectopic Shh expression at the ant...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2005
ISSN: 1058-8388,1097-0177
DOI: 10.1002/dvdy.20254